In Kentucky, five sexy students are trapped to spend the night in an abandoned sanatorium, where many people were killed in the 30's when the location was devastated by an infectious white plague, as a prank of their school mates. Along the night, while trying to escape from the asylum, they are haunted by ghosts and the survivors disclose that they are descendant of the victims and are reviving their deaths.

Soon after moving in, Beth, a brainy, beautiful writer damaged from a past relationship encounters Adam, the handsome, but odd, fellow in the downstairs apartment whose awkwardness is perplexing. Beth and Adam's ultimate connection leads to a tricky relationship that exemplifies something universal: truly reaching another person means bravely stretching into uncomfortable territory and the resulting shake-up can be liberating.

Rizwan Khan, a Muslim from the Borivali section of Mumbai, suffers from Asperger's syndrome, a form of high-functioning autism that complicates socialization. The adult Rizwan marries a Hindu single mother, Mandira, in San Francisco. After 9/11, Rizwan is detained by authorities at LAX who mistake his disability for suspicious behavior. Following his arrest, he meets Radha, a therapist who helps him deal with his situation and his affliction. Rizwan then begins a journey to meet US President Obama to clear his name.